Optical whispering-gallery-mode (WGM) cavities have gained appreciable curiosity due to their distinctive properties of light-matter interactions enhancement. Standard WGM sensing relies on the mechanisms of mode shift, mode broadening, or mode splitting, which requires a small mode quantity and an ultrahigh Q-factor. In addition to, the WGM sensing suffers from an absence of the specificity in figuring out substance, and extra chemical functionalization or the incorporation of plasmonic supplies are required for good specificity. Herein, we suggest a brand new sensing technique based mostly on a person WGM cavity to realize ultrasensitive and high-specificity molecular sensing, which mixes the options of enhanced light-matter interactions on WGM cavity and the “fingerprint spectrum” of surface-enhanced Raman scattering (SERS). This technique identifies the substance by monitoring the Raman sign enhanced by WGM cavity quite than monitoring the variation of WGM itself. Subsequently, ultrasensitive and high-specificity molecular sensing may be completed even on a low-Q cavity. The working rules of the proposed sensing technique have been additionally systematically investigated when it comes to photoinduced cost switch, Purcell impact, and optical resonance coupling. This work offers a brand new WGM sensing method in addition to a technique within the design of high-performance SERS substrate by creating optical resonance mode.