Nucleic acid therapies involving DNA or RNA have vital potential to deal with genetic problems, infectious ailments, and most cancers; nonetheless, analysis means that lower than 1% of injected nucleic acid doses attain goal cells in an energetic kind. An article in WIREs Nanomedicine and Nanobiotechnology highlights two of the main limitations to this therapeutic technique, and the way they may be overcome.
Supply to the goal cell and transport to the sub-cellular compartment the place the nucleic acids are therapeutically energetic symbolize essentially the most vital challenges to handle. The authors discover how nanoparticle supply techniques could be modified with focusing on molecules to extend accumulation in particular cells, and the way the composition of the nanoparticle could be engineered to govern or disrupt mobile membranes and facilitate supply to the optimum sub-cellular compartments.
“Controlling the sub-cellular supply of DNA and RNA is the subsequent main frontier for biotherapeutics. If we will overcome these limitations, DNA and RNA expertise has the potential to revolutionize the therapy of a variety of ailments,” mentioned corresponding writer Angus P.R. Johnston, Ph.D., of Monash College, in Australia.
Lara M. Mollé et al, Nanoparticles for vaccine and gene remedy: Overcoming the limitations to nucleic acid supply, WIREs Nanomedicine and Nanobiotechnology (2022). DOI: 10.1002/wnan.1809
Overcoming challenges within the supply of nucleic acid therapeutics (2022, November 23)
retrieved 23 November 2022
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